Posted by
Savannah Momo on Monday, November 30, 2009 2:31:57 AM
Fluorine-containing pyridine intermediates into the hot At present,
China has developed and has been put into mass production of the quinolone
antibacterial drugs are mainly norfloxacin, ciprofloxacin, ofloxacin, enoxacin,
lomefloxacin and fluorine Rosa magnitude. Including norfloxacin, ciprofloxacin,
ofloxacin produce the largest, accounting for fluoroquinolone antibacterial
agents of domestic production of 98%.
Quinolones are generally synthetic
fluorine-containing fluorine-containing benzene ring after quinoline piperazine
compounds (or methyl piperazine) derived from condensation. Because China's
abundant reserves of fluorite, which is the world's production of
fluorine-containing drugs and intermediates, one of the largest countries, with
more than 80% of the export supply of fluorine-containing intermediates.
Overall, the development of China-fluorobenzene intermediate class early, the
current excess production capacity generally; Benzotrifluoride the development
of late
pharmaceutical intermediates class in recent years, fast development; while for
heterocyclic aromatic compounds, especially fluorinated pyridine class, our
present, only the individual research units and production plants have a
fluorine-containing pyridine intermediate synthesis technology, therefore,
fluorine-containing pyridine intermediates will be the next few years, the
domestic development of fluorine-containing intermediates, one of the main
directions.
For example: Chloromethyl Pivalate
Aminophenol big gap in China has become the world's largest
Pharmaceutical Intermediates manufacturers
of anti-inflammatory drugs, aspirin, paracetamol, and other types of output
Junchao analgin million tons, phenacetin, aminopyrine, security other than the
forest species for production of more than 1000 tons. At present, China's output
of antipyretic analgesics has grown rapidly in the future will be expected to
grow at a rate of about 8%. For the complete production of antipyretic
analgesics intermediate output of large manufacturing enterprises more. With the
growth of anti-inflammatory drugs, their intermediates have also gained
considerable development.