Posted by
Savannah Momo on Thursday, November 12, 2009 2:30:56 AM
Organocatalysis uses small organic molecules predominantly composed of C, H,
O, N, S and P to accelerate chemical reactions. The advantages of organocatalysts
include their lack of sensitivity to moisture and oxygen, their ready
availability, low cost, and low toxicity, which confers a huge direct benefit in
the production of pharmaceutical intermediates when compared with (transition)
metal catalysts.
In the example of the N-BOC-4-Hydroxypiperidine,it is believed that piperidine forms a reactive iminium ion intermediate with the carbonyl compound:
Description: N-BOC-4-Hydroxypiperidine
Synonym: N-(Tert-Butoxycarbonyl)-4-Hydroxypiperidine
CAS: 109384-19-2
Assay: ≥98% (GC)
Appearance: white or off-white powder
Molecular: C10H19NO3
Application: Pharmaceutical Intermediates